We are looking for people with jaw muscle pain to take part in a trial of new and existing treatments

You may be eligible to participate if you:

  • Are 18 years of age or greater.

  • Have had jaw muscle pain (myalgia Temporomandibular Disorder [TMD]) for 3 months or more

  • Exercises and advice haven’t helped your pain

  • Can answer “Yes” to both of the following two questions:

1.Do you have pain in your temple, face, jaw or jaw joint once a week or more?

2. Do you have pain once a week or more when you open your mouth or chew?

What will participation involve?

  • Participation involves 36 weeks of treatment with either:

  1. Daily medication: Amitriptyline (Antidepressant) or Gabapentin (Anti-epileptic)

OR

2. An injectable treatment to the sore muscles every twelve weeks. Either lidocaine (numbing injection like at the dentist) OR Botox.

  • You’ll complete questionnaires a maximum of 4-5 times over 36 weeks and attend up to 5 in-person or virtual visits for check-ups or injection treatment.

  • Reasonable travel expenses up to a total of £27/visit will be reimbursed. We will have 12 sites across England, Wales & Scotland where we can perform the trial.

If you’d like to ask questions or self-refer for an eligibility assessment please email nuth.mitigate@nhs.net with your name, age, and your nearest major town.